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Human HGF plasmid DNA therapy : ウィキペディア英語版 | Human HGF plasmid DNA therapy Human HGF plasmid DNA therapy of cardiomyocytes is being examined as a potential treatment for coronary artery disease (a major cause of myocardial infarction (MI)), as well as treatment for the damage that occurs to the heart after MI.〔 After MI, the myocardium suffers from reperfusion injury which leads to death of cardiomyocytes and detrimental remodelling of the heart, consequently reducing proper cardiac function.〔 Transfection of cardiac myocytes with human HGF reduces ischemic reperfusion injury after MI. The benefits of HGF therapy include preventing improper remodelling of the heart and ameliorating heart dysfunction post-MI.〔〔 ==Human hepatocyte growth factor== Human hepatocyte growth factor (HGF) is an 80kD pleiotropic protein that is endogenously produced by a variety of cell types from the mesenchymal cell lineage (such as cardiomyocytes and neurons). It is produced and proteolytically cleaved to its active state in response to cellular injury or during apoptosis. HGF binds to c-met receptors found on mesenchymal cell types to produce its many different effects such as increased cellular motility, morphogenesis, proliferation and differentiation. Research has shown that HGF has potent angiogenic, anti-fibrotic, and anti-apoptotic properties.〔 It has also been shown to act as a chemoattractant for adult mesenchymal stem cells via c-met receptor binding.〔〔
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